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Title   유방암에서 수술후 방사선 치료 결과 ( Results of Postoperative Radiation Therapy in 77 Patients of Breast Cancer )
Publicationinfo   1997 Jan; 029(06): 1049-1061.
Key_word   Breast cancer, Postoperative radiation therapy,Locoregional control,Sutival
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Abstract   Purpose: This retrospective study was performed to evaluate the effect of postoperative adjuvant radiation therapy of breast cancer on survival, failure patterns and to identify unfavorable prognostic factors. Meterials and Methods: Seventy-seven patients were analysed retrospectively. Median follow up period was 72 months. According to AJCC system, fifty-eight patients(75%) were advanced than Stage IIb. Among 77 patients, 66 patients(86%) received mastectomy and axillary LN dissection and the other 11 patients (14%) received partial mastectomy and axillary LN dissection. Postoperative radiation therapy with 6 MV X-ray was given to the chest wall and regional lymphatics with total dose of 50 to 55 Gy. Fifty-five patients(71%) received CMF or CAF chemotherapy prior to or after radiation therapy. Results: The 5 year and 10 year survival rate were 64.4% and 51.3%, respectively and 5 year and 10 year disease free survival rate were 57.6% and 47.5%, respectively. Median survival duration was 91 months. Of the 77 patients, 59 patients were evaluable for pattern of failure. Of these, eighteen patients(31%) failed. Initial failure pattern was as follow: 7 (12%) at locoregional, 3(5%) in distant metastasis, 8(14%) with locoregional and distant metastasis. But the pattern of final failure at the time of last follow up was contrasted. Distanf failure was the predominant pattern of failure with 29% of patients. Overall survival and disease free survival was significantly influenced by 6 factors with univariated analysis(p<0.05): AJC Stage, T stage, N Stage, number of involved axilliary LN, SCL LN mets, failure pattern. By multivariate analysis the survival difference continued to be significant in 3 factors: T stage, number of involved axillary LN, failure pattern. Conclusion: These data demonstrate high locoregional control and survival rate using the combination of surgery and radiotherapy for the patients with locally advanced breast cancer. But predominant failure pattern was distant dissemination. Therefore more effective systemic therapy is needed to improve overall survival.
저 자   김연실(Yeon Shil Kim),장흥석(Hong Seok Jang),유미령(Mi Ryeong Ryu),김성환(Sung Hwan Kim),정상설(Sang Seol Jung),윤세철(Sei Chul Yoon),김인철(In Chul Kim),신경섭(Kyung Sub Shinn)